F-18 LABELED TRIAZANONANE DERIVATIVES OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF FOR HYPOXIC TISSUE IMAGING

• Main Authors: CHUNG, JUNE KEY, HOIGEBAZAR LATHIKA, JEONG, JAE MIN, LEE, DONG SOO, LEE, MYUNG CHUL
• Format: Patent
• Language: English; Korean
• Published: 12.12.2012
• Subjects: ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM; CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

PURPOSE: A fluorine-18 labeled triazanonane derivative for ischemic tissue imaging is provided to stably form a complex and to enable PET(Positron Emission Tomography) for determining stroma, cerebrovascular diseases, cancer, nervous diseases, and coronary artery diseases. CONSTITUTION: A triazanonane derivative is denoted by chemical formula 1. The derivative of chemical formula 1 forms a complex together with metals and fluoride. The metal includes aluminum, gallium, indium, thallium, yttrium, or ruthenium. A radiopharmaceutical product contains the derivative of chemical formula 1 and the complex of metals and fluoride as an active ingredient. A method for preparing the derivative of chemical formula 1 comprises: a step of dissolving NODA compounds of chemical formula 2 and a base in an organic solvent; a step of adding nitroimidazole or nitrotriazole compounds to prepare a compound of chemical formula 3; and a step of dissolving the compound of chemical formula 3 in the organic solvent and performing deprotection. [Reference numerals] (AA) Step 1; (BB) Step 2