NOVEL THIOPHENE CARBOXAMIDE DERIVATIVE AND MEDICINAL USE OF SAME

• Main Authors: CHIKAMATSU KAORI, MIYOSHI MIKA, MURAKAMI SEI, YAMASHITA TOKUYUKI, IWAI HISAKAZU, IZUCHI TOHRU, GOTO IZUMI, KASUGAI NOBUYOSHI, FUJIEDA HIROKI, MIYAZAWA TOSHIYUKI, SUZUKI KIMIE, KATAOKA DAISUKE, SEIFERT HANS JUERGEN MARKUS, LANG MARTIN, WOLF KAARINA KRISTINA, KATO NORIYASU, TSURUTA NOBUAKI, KATAOKA HIROYO, HIRAMATSU NAOKI, SAKAIRI MASAO, YAMADA YURIE, WATANABE NOBUHIDE, HARADA SATOKO, TAKAHASHI NAOKI, MAKINO MITSUHIRO, NAGAI KAZUSHIGE, KOGAMI MASAKAZU
• Format: Patent
• Language: English; Korean
• Published: 29.08.2012
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The object of the present invention is to provide a compound having a glucokinase-activating effect. A pharmaceutical composition comprising a compound represented by the general formula (I) or a pharmaceutically acceptable salt thereof as an active ingredient: wherein X means a nitrogen atom or CR 6 wherein R 6 means a hydrogen atom or a halogen atom; R 1 means a hydrogen atom, a C1-C6 alkyl group, a C1-C6 alkoxy group or a C1-C6 alkylthio group; R 2 means a hydrogen atom or a fluorine atom; R 3 means a hydrogen atom or a C1-C6 alkyl group; and one of R 4 and R 5 means a hydrogen atom or a C1-C6 alkyl group, and the other means a C1-C6 alkylenecarboxylic acid, a C1-C6 alkylsulfonyl group, a C1-C6 alkylcarbonyl group, or CONH 2 .