NANOPARTICLES FORMED BY ENCAPSULATING AN ANTICANCER DRUG INTO GLYCOLCHITOSAN-CHOLANIC ACID COMPLEX AND A PROCESS FOR THE PREPARATION THEREOF

PURPOSE: A nanoparticle having a glycolchitosan-bile acid composite containing a hydrophtic anticancer agent is provided to ensure excellent water solubility and to be used as an injector. CONSTITUTION: A nanoparticle is prepared by sealing a glycolchitosan-bile acid composite containing a hydrophot...

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Main Authors PARK, CHI HYE, HONG, HYE SUK, LEE, JU HYUN, YOON, MYEONG SIK, KIM, YU MI, HONG, EUN MI, LIM, SUN KYUNG, LEE, JUNG ROK, LEE, HA YOUNG, CHO, IL HWAN, PARK, JIE EUN
Format Patent
LanguageEnglish
Korean
Published 26.07.2012
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:PURPOSE: A nanoparticle having a glycolchitosan-bile acid composite containing a hydrophtic anticancer agent is provided to ensure excellent water solubility and to be used as an injector. CONSTITUTION: A nanoparticle is prepared by sealing a glycolchitosan-bile acid composite containing a hydrophotic anticancer agent. The molecular weight of glycolchitosan monomers is 10-20 kDa. The diameter of the particle is 100-200 nm. The hydrophobic anticancer agent is daunoamicin, docetaxel, paclitaxel, cisplatin, mitomycin-C or 5-fluorouracil. An injector contains the nanoparticles.
Bibliography:Application Number: KR20110004989