DI - SUBSTITUTED PYRIDINE DERIVATIVES AS ANTICANCERS

The present invention provides a novel compound having an excellent antitumor effect. The compound of the present invention is represented by the following general formula (1) wherein R1 and R2 are aryl or the like; A is lower alkylene; Ring X is optionally substituted arylene; E is bond or lower al...

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Main Authors YAMADA SATOSHI, MIYAJIMA KEISUKE, SUGIYAMA KAZUHISA, YANAGIHARA YASUO, OKUNO MITSUHIRO, KOJIMA YUTAKA, SAKAI KOJI, SATO YOSUKE, FUJITA SHIGEKAZU, TANAKA HIDEO, SUMIDA TAKUMI, SUZUKI TAKASHI, TAKASU HIDEKI, HIROSE TOSHIYUKI, SEKIGUCHI KAZUO, OHTSUKA SHINYA
Format Patent
LanguageEnglish
Korean
Published 20.06.2012
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present invention provides a novel compound having an excellent antitumor effect. The compound of the present invention is represented by the following general formula (1) wherein R1 and R2 are aryl or the like; A is lower alkylene; Ring X is optionally substituted arylene; E is bond or lower alkenylene; Ring Y is optionally substituted heterocycloalkylene containing one or more nitrogen atoms, one of which is attached to the adjacent carbonyl group; G is -NH-G2-, -N(lower alkyl)-G2-, -NH-CH2-G2-, -N(lower alkyl)-CH2-G2- or -CH2-G2-, [wherein G2 binds to R2, G2-R2 is bond-R2, phenylene-G3-R2, phenylene-G4-O-R2, phenylene-G5-NH-R2, phenylene-G6-N(lower alkyl)-R2 or quinolinediyl-O-R2, the phenylene of said phenylene-containing groups being optionally substituted with one or more substituents; G3-R2 is -O-lower alkylene-R2 or the like; G4-O- is lower alkylene-O- or the like; G5 is lower alkylene; G6 is lower alkylene].
Bibliography:Application Number: KR20117025212