COMPOSITION AND METHODS OF USE FOR THERAPEUTIC ANTIBODIES SPECIFIC FOR THE IL-12 RECEPTORE BETAL SUBUNIT

• Main Authors: DELLA DUCATA DANIELA, CARBALLIDO HERRERA JOSE M, BARDROFF MICHAEL, HEUSSER CHRISTOPH, JAEGER UTE, SCHWAERZLER CHRISTOPH
• Format: Patent
• Language: English; Korean
• Published: 05.06.2012
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

The present invention relates to antibodies that specifically bind to IL12R 1, the non-signal transducing chain of the heterodimeric IL12 receptor (together with IL12R 2 chain) as well as IL23 receptor (together with IL23Rα chain). The invention more specifically relates to specific antibodies that are IL12 and IL23 receptor antagonists capable of inhibiting IL12/IL18 induced IFNγ production of T cells and compositions and methods of use for said antibodies to treat pathological disorders that can be treated by inhibiting IFNγ production, such as rheumatoid arthritis, psoriasis or inflammatory bowel diseases or other autoimmune and inflammatory disorders.