METHOD FOR SYNTHESIZING 4-O-METHYLHONOKIOL

PURPOSE: A synthesizing method of 4-O-methylhonokiol is provided to mass-product 4-I-methylhonokiol with higher purity and higher yield by existing method extracting from natural material. CONSTITUTION: A synthesizing method of 4-O-methylhonokiol comprises a step of synthesizing 4-alkyl-2-bromopheno...

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Bibliographic Details
Main Authors LEE, HEE SOON, KWAK, YOUNG SHIN, JUNG, JAE KYUNG, CHO, YOUNG AE, KWAK, JAE HWAN
Format Patent
LanguageEnglish
Korean
Published 30.04.2012
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
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Summary:PURPOSE: A synthesizing method of 4-O-methylhonokiol is provided to mass-product 4-I-methylhonokiol with higher purity and higher yield by existing method extracting from natural material. CONSTITUTION: A synthesizing method of 4-O-methylhonokiol comprises a step of synthesizing 4-alkyl-2-bromophenol by substituting bromine at the ortho location of 4-allylphenol; a step of synthesizing potassium 3-allyl-4-methoxyphenyltrifluoroborate from 2-allyl-4-bromo-1-anisole, and a step of synthesizing 4-O-methylhonokiol through Suzuki-Miyaura coupling reaction of 4-allyl-2-bromophenol, and potassium 3-allyl-4-methoxyphenyltrifluoroborate.
Bibliography:Application Number: KR20100102491