A NOVEL CURCUMIN DERIVATIVE WITH IMPROVED WATER SOLUBILITY AND STABILITY COMPARED WITH CURCUMIN AND METHOD THEREOF

PURPOSE: A curcumin derivative is provided to have remarkably improved water solubility and stability in environment outside cells comparison to existing curcumin, while having cytotoxin eual to curcumin, and to be able to improve bio-availability. CONSTITUTION: A diketo or keto-enol formed compound...

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Bibliographic Details
Main Authors KIM, MI KYOUNG, CHONG, YOU HOON
Format Patent
LanguageEnglish
Korean
Published 30.04.2012
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:PURPOSE: A curcumin derivative is provided to have remarkably improved water solubility and stability in environment outside cells comparison to existing curcumin, while having cytotoxin eual to curcumin, and to be able to improve bio-availability. CONSTITUTION: A diketo or keto-enol formed compound is in chemical formula 4. A manufacturing method of the compound in chemical formula 4 comprises: a step of obtaining 3-acetoxyacetylacetone by dissolving 3-chloroacetoacetone into dimethylsulfoxide, and adding sodium acetate; and a step of dissolving boric oxide into dimethylsulfoxide, adding and mixing tributyl borate and the 3-acetoxyacetylacetone, and adding and mixing 3,4-dihydroxy-5-methoxybenzaldehyde, and adding 1,2,3,4- tetrahydroquionoline and acetic acid diluted to dimethylformamide.
Bibliography:Application Number: KR20100102489