AKT PROTEIN KINASE INHIBITORS

The present invention provides compounds, including resolved enantiomers, diastereomers, solvates and pharmaceutically acceptable salts thereof, comprising the Formula: A-L-CR where CR is a cyclical core group, L is a linking group and A is as defined herein. Also provided are methods of using the c...

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Main Authors MILLER SCOTT, XIAO DENGMING, BLAKE JAMES, PISCOPIO ANTHONY, XU RIU, WANG BIN, SPENCER KEITH L, MUNSON MARK, VIGERS GUY P. A, MITCHELL IAN S, RAO CHANG, HAN YONGXIN, JOSEY JOHN, KALLAN NICHOLAS C, STENGEL PETER, BERNACKI APRIL L
Format Patent
LanguageEnglish
Korean
Published 23.12.2011
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present invention provides compounds, including resolved enantiomers, diastereomers, solvates and pharmaceutically acceptable salts thereof, comprising the Formula: A-L-CR where CR is a cyclical core group, L is a linking group and A is as defined herein. Also provided are methods of using the compounds of this invention as AKT protein kinase inhibitors and for the treatment of hyperproliferative diseases such as cancer.
Bibliography:Application Number: KR20117028995