RELEASE CONTROLLED PHARMACEUTICAL COMPOSITION COMPRISING TRAMADOL OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, AND ORAL DOSAGE FORM COMPRISING THE COMPOSITION

PURPOSE: A pharmaceutical composition containing tramadol or pharmaceutically acceptable salt thereof is provided to prevent quick release of active ingredients with minimized side effect. CONSTITUTION: A pharmaceutical composition comprises: a core containing tramadol or pharmaceutically acceptable...

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Main Authors CHUNG, HO JIN, SEO, MOON GUN, LIM, HYE JUNG, PAI, CHAUL MIN, PARK, SANG YEOB
Format Patent
LanguageEnglish
Korean
Published 10.11.2011
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:PURPOSE: A pharmaceutical composition containing tramadol or pharmaceutically acceptable salt thereof is provided to prevent quick release of active ingredients with minimized side effect. CONSTITUTION: A pharmaceutical composition comprises: a core containing tramadol or pharmaceutically acceptable salt thereof; and a plurality of microspheres containing a polymer coating layer for controlling release. The polymer of the polymer coating layer comprises different first and second microspheres. The average thickness ratio of the coating layer of the first and second microspheres is 1: 1.2-8. The coating layer contains water insoluble polymers.
Bibliography:Application Number: KR20100041691