CANCER CELL SPECIFIC EXPRESSION VECTOR CONTAINING DELETED MUTANT PROMOTER OF PROMOTER OF PRC1

PURPOSE: An expression vector containing cancer cell-specific overexpression promoter is provided to treat cancer. CONSTITUTION: A cancer cell-specific expression vector contains a mutation promoter in which a part of cytokinesis 1 protein regulator 1(PRC 1) gene promoter upstream is deleted. The pa...

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Bibliographic Details
Main Authors LEE, HEUI RAN, CHO, YOUNG HWA, PARK, KEE RANG, SEOL, WON GI, JEONG, SUN JOO
Format Patent
LanguageEnglish
Korean
Published 03.08.2011
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPIRITS
VINEGAR
WINE
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Summary:PURPOSE: An expression vector containing cancer cell-specific overexpression promoter is provided to treat cancer. CONSTITUTION: A cancer cell-specific expression vector contains a mutation promoter in which a part of cytokinesis 1 protein regulator 1(PRC 1) gene promoter upstream is deleted. The part is 1-1,289bp from the upstream end. The mutation promoter is selected from sequence numbers 6-9. The expression vector additionally contains cancer cell apoptotic gene. The expression vector is a recombinant AAV vector. The cancer cell apoptotic gene is a pro-apoptotic gene or death receptor/ligand gene. The pro-apoptotic gene is Bax(BCL2-associated X) or Bad(BCL2-antagonist of cell death). The death receptor/ligand gene is TNF-alpha or Fas ligand.
Bibliography:Application Number: KR20100007500