8-PHENYL-6A,7,8,9,9A,10-HEXAHYDRO-6H-ISOINDOLO[5,6-G]QUINOXALINE-7,9-DIONE(PHID) WITH NEURONAL CELL DEATH INHIBITORY ACTIVITY AND THE PHARMACEUTICAL COMPOSITION COMPRISING THE SAME FOR PREVENTION AND TREATMENT OF NEURODEGENERATIVE DISEASE

• Main Authors: LEE, HEE SOON, CHOI, DONG KUG, KIM, IN SU
• Format: Patent
• Language: English; Korean
• Published: 08.06.2011
• Subjects: FOODS OR FOODSTUFFS; FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BYSUBCLASSES A23B - A23J; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OFNUTRITIVE QUALITIES, PHYSICAL TREATMENT; THEIR TREATMENT, NOT COVERED BY OTHER CLASSES

PURPOSE: A composition containing PHID compound(8-phenyl-6a,7,8,9,9a,10-hexahydro-6H-isoindolo[5,6-g]quinoxaline-7,9-dione) is provided to suppress Akt and c-Jun phosphorylation and to prevent and treat neurodegenerative diseases. CONSTITUTION: A PHID(8-phenyl-6a,7,8,9,9a,10-hexahydro-6H-isoindolo[5,6-g]quinoxaline-7,9-dione) compound has an activity of suppressing nerve cell apoptosis and is denoted by chemical formula 1. A pharmaceutical composition for preventing and treating neurodegenerative diseases contains PHID compound of chemical formula 1 as an active ingredient. A health food for preventing and treating neurodegenerative diseases contains PHID compound of chemical formula 1 as an active ingredient. The health food is manufactured in the form of tablet, pill, capsule, or liquid.