SUBSTITUTED 1,2,3,4- TETRAHYDROCYCLOPENTA[B]INDOL-3-YL) ACETIC ACID DERIVATIVES USEFUL IN THE TREATMENT OF AUTOIMMUNE AND INFLAMMATORY DISORDERS

The present invention relates to certain substituted 1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid derivatives of Formula (Ia) and pharmaceutically acceptable salts thereof, which exhibit useful pharmacological properties, for example, as agonists of the S1P1 receptor.Also provided by the pr...

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Main Authors MOODY JEANNE V, ZHU XIUWEN, JONES ROBERT M, ULLMAN BRETT, BUZARD DANIEL J, HAN, SANG DON, LEHMANN JUERG, STIRN SCOTT, KIM, SUN HEE
Format Patent
LanguageEnglish
Korean
Published 05.04.2011
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Summary:The present invention relates to certain substituted 1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid derivatives of Formula (Ia) and pharmaceutically acceptable salts thereof, which exhibit useful pharmacological properties, for example, as agonists of the S1P1 receptor.Also provided by the present invention are pharmaceutical compositions containing compounds of the invention, and methods of using the compounds and compositions of the invention in the treatment of S1P1 receptor-associated disorders, for example, psoriasis, rheumatoid arthritis, Crohn's disease, transplant rejection, multiple sclerosis, systemic lupus erythematosus, ulcerative colitis, type I diabetes, acne, microbial infections or diseases and viral infections or diseases.
Bibliography:Application Number: KR20117004027