CROSSLINKED HYDROGELS

• Main Authors: KITA KRISTIN, KEANE MICHAEL F, LOWMAN ANTHONY M, SMITH NIGEL G, FUSSELL GARLAND W
• Format: Patent
• Language: English; Korean
• Published: 14.03.2011
• Subjects: CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES; CHEMISTRY; COMPOSITIONS BASED THEREON; DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROMTHE BODY; DIAGNOSIS; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; HUMAN NECESSITIES; HYGIENE; IDENTIFICATION; MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONSONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES; MEDICAL OR VETERINARY SCIENCE; METALLURGY; METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL; ORGANIC MACROMOLECULAR COMPOUNDS; SURGERY; THEIR PREPARATION OR CHEMICAL WORKING-UP

The present invention preferably provides for a method of forming and the resulting solid polymer gel composition comprising polyethylene imine and at least one hydrogen bonding polymer. The composition has a greater viscosity than either of the polyethylene imine or the hydrogen bonding polymer alone and is injectable immediately after mixing of the polyethylene imine and the at least one hydrogen bonding polymer. A method of tissue repair may include mixing about 9.25% (w/w) to about 13.65% (w/w) polyethylene imine and about 18.02% (w/w) to about 26.62% (w/w) polyvinyl alcohol to form an injectable composition; injecting the injectable composition into a cavity within a human body; and allowing the composition to solidify in situ. A kit may include a multi-barrel syringe at least one barrel is loaded with polyethylene imine and at least another barrel is loaded with at least one hydrogen bonding polymer.