NOVEL DISUBSTITUTED PHENOXYACETYL BASED COMPOUND OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, PREPARATION METHOD THEREOF AND PHARMACEUTICAL COMPOSITION FOR INHIBITION OF MULTIDRUG RESISTANCE CONTAINING THE SAME AS AN ACTIVE INGREDIENT
PURPOSE: A disubstituted phenoxyacetyl-based compound is provided to increase an inhibitory activity to overexpression of P-glycoprotein and an anticancer activity in administration with an anti-cancer drug and to reduce side effects on normal cells. CONSTITUTION: A disubstituted phenoxyacetyl-based...
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Main Authors | , , , , |
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Format | Patent |
Language | English Korean |
Published |
09.02.2011
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Subjects | |
Online Access | Get full text |
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Summary: | PURPOSE: A disubstituted phenoxyacetyl-based compound is provided to increase an inhibitory activity to overexpression of P-glycoprotein and an anticancer activity in administration with an anti-cancer drug and to reduce side effects on normal cells. CONSTITUTION: A disubstituted phenoxyacetyl-based compound or pharmaceutically acceptable salts thereof are represented by chemical formula 1. In chemical formula 1, R^1 and R^2 are X-Y-Z, X-Z or Z, wherein Z is a functional group of chemical formula 1-1 or 1-2; Y is -(CH2)-n, wherein n is an integer of 1~5 and Z is amino, phenyl, quinolinyl or isoquinolinyl, in which the amino, phenyl, quinolinyl or isoquinolinyl are substituted or unsubstituted. |
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Bibliography: | Application Number: KR20090069700 |