CONJUGATED FACTOR VIII MOLECULES

The invention concerns B-domain truncated Factor VIII molecules with a modified circulatory half-life, wherein the molecules are covalently conjugated with a hydrophillic polymer via an O-linked oligosaccharide in the truncated B domain, and wherein factor VIII activation results in removal of the c...

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Bibliographic Details
Main Authors VANDAHL BRIAN BERG STIDSEN, STEENSTRUP THOMAS DOCK, BOLT GERT, THIM LARS, STENNICKE HENNING RALF, DEFREES SHAWN
Format Patent
LanguageEnglish
Korean
Published 25.01.2011
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The invention concerns B-domain truncated Factor VIII molecules with a modified circulatory half-life, wherein the molecules are covalently conjugated with a hydrophillic polymer via an O-linked oligosaccharide in the truncated B domain, and wherein factor VIII activation results in removal of the covalently conjugated hydrophillic polymer, as well as pharmaceutical compositions comprising said Factor VIII molecules.
Bibliography:Application Number: KR20107018763