A PROBE FOR DETECTION OF DRUG RESISTANCE OF MYCOBACTERIUM TUBERCULOSIS AND THE KIT

PURPOSE: A probe, kit and method for diagnosing resistance to a drug for tuberculosis are provided to effectively treat tuberculosis. CONSTITUTION: A gene probe for diagnosing resistance to a drug for tuberculosis is selected from sequence numbers 23-30, 31, 32, 33-36, 37-41, 42-53, 54-57 or 58-67....

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Main Authors BANG, HYE EUN, CHO, SANG NAE, KANG, MI RAN, WANG, HYE YOUNG, LEE, HYE YOUNG
Format Patent
LanguageEnglish
Korean
Published 13.01.2011
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS OR TEST PAPERS THEREFOR
COMPOSITIONS THEREOF
CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES
CULTURE MEDIA
ENZYMOLOGY
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
PROCESSES OF PREPARING SUCH COMPOSITIONS
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPIRITS
VINEGAR
WINE
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Summary:PURPOSE: A probe, kit and method for diagnosing resistance to a drug for tuberculosis are provided to effectively treat tuberculosis. CONSTITUTION: A gene probe for diagnosing resistance to a drug for tuberculosis is selected from sequence numbers 23-30, 31, 32, 33-36, 37-41, 42-53, 54-57 or 58-67. The drug for tuberculosis is rifampin, isoniazid, ofloxacin, kanamycin or streptomycin. A composition for diagnosing resistance to a drug for tuberculosis contains the probe and a primer for amplifying Mycobacterium tuberculosis. A kit for diagnosing the resistance contains the probe and primer. A method for diagnosing the drug resistance comprises: a step of attaching the probe to a solid support; a step of hybridizing amplified PCR product of Mycobacterium tuberculosis with the probe; and a step of detecting hybridized product.
Bibliography:Application Number: KR20100038364