PHARMACEUTICAL TABLET
A method of preparing a pharmaceutical dosage form having a first and second active drug, comprising (a) forming a controlled release core comprising metformin or a pharmaceutically acceptable salt thereof and at least one pharmaceutically acceptable excipient; (b) coating a coating solution on said...
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Main Authors | , , , |
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Format | Patent |
Language | English Korean |
Published |
29.12.2010
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Subjects | |
Online Access | Get full text |
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Summary: | A method of preparing a pharmaceutical dosage form having a first and second active drug, comprising
(a) forming a controlled release core comprising metformin or a pharmaceutically acceptable salt thereof and at least one pharmaceutically acceptable excipient;
(b) coating a coating solution on said controlled release core to form an immediate release coating, said coating solution comprising:
(i) pioglitazone or a pharmaceutically acceptable salt thereof;
(ii) water;
(iii) an organic solvent;
(iv) a binder;
(v) optionally a surfactant;
(vi) optionally a pore forming agent;
wherein the ratio of water to organic solvent is 50:50 to 2:98, and the ratio of binder to pioglitazone or the salt thereof is 1:9 to 1:11;
wherein said dosage form releases not less than 75% of the pioglitazone or the salt thereof from the dosage form within 0.5 hour when tested in a United States Pharmacopeia (USP) Type 2 apparatus at 75 rpm in 900 ml of simulated intestinal fluid (pH 7.5 phosphate buffer) and at 37°C. |
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Bibliography: | Application Number: KR20107027556 |