PROCESS FOR PREPARING ALKYL 2-ALKOXYMETHYLENE-4,4-DIFLUORO-3-OXOBUTYRATES

A process for preparing alkyl 2-alkoxymethylene-4,4-difluoro-3-oxobutyrates (VI) where R is methyl or ethyl, from crude reaction mixtures of alkyl 4,4-difluoroacetoacetates (I) by a) reacting  where M is a sodium or potassium ion, and  without additional solvent to form an enolate (V) b) releasing t...

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Main Authors KORADIN CHRISTOPHER, WOLF BERND, ZIERKE THOMAS, SMIDT SEBASTIAN PEER, MAYWALD VOLKER, RACK MICHAEL, KEIL MICHAEL
Format Patent
LanguageEnglish
Korean
Published 21.12.2010
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
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Summary:A process for preparing alkyl 2-alkoxymethylene-4,4-difluoro-3-oxobutyrates (VI) where R is methyl or ethyl, from crude reaction mixtures of alkyl 4,4-difluoroacetoacetates (I) by a) reacting  where M is a sodium or potassium ion, and  without additional solvent to form an enolate (V) b) releasing the corresponding alkyl 4,4-difluoroacetoacetate (I) from the enolate (V) by means of acid, c) removing the salt formed from cation M and acid anion as a solid and d) converting (I), without isolation from the crude reaction mixture, to the alkyl 2-alkoxymethylene-4,4-difluoro-3-oxobutyrate (VI), and the use of (VI) for preparing 1-methyl-3-difluoromethyl-pyrazol-3-ylcarboxyates VII
Bibliography:Application Number: KR20107021594