SUBSTITUTED SPIROCYCLIC PIPERIDINE DERIVATIVES AS HISTAMINE-3 (H3) RECEPTOR LIGANDS

The present invention is directed to methods of treating disorders mediated by Histamine H3 receptors by administering novel substituted spirocyclic piperidine derivatives according to Formula (I). In particular, the substituted spirocyclic piperidine derivatives may be effective in the treatment of...

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Bibliographic Details
Main Authors SUNDAR BABU G, DANDU REDDEPPAREDDY, HUDKINS ROBERT L
Format Patent
LanguageEnglish
Korean
Published 29.09.2010
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present invention is directed to methods of treating disorders mediated by Histamine H3 receptors by administering novel substituted spirocyclic piperidine derivatives according to Formula (I). In particular, the substituted spirocyclic piperidine derivatives may be effective in the treatment of diseases or disease states, including narcolepsy or sleep/wake disorders, feeding behavior disorders, eating disorders, obesity, cognition disorders, arousal disorders, memory disorders, mood disorders, mood attention alteration, attention deficit hyperactivity disorder (ADHD), Alzheimer's disease/dementia, schizophrenia, pain, stress, migraine, motion sickness, depression, psychiatric disorders, epilepsy, gastrointestinal disorders, respiratory disorders, inflammation, and myocardial infarction.
Bibliography:Application Number: KR20107019040