MUTIFUNCTIONAL CONTRAST AGENT USING BIOCOMPATIBLE POLYMER AND PREPARATION METHOD

• Main Authors: KIM, HYO JEONG, KIM, BYUNG JIN, HA, DAE CHUL, CHOI, YOUN WOONG, CHO, SUN HANG, MIN, BYUNG GU, SEONG, HA SOO, SHIN, BYUNG CHEOL, YUK, SOON HONG
• Format: Patent
• Language: English; Korean
• Published: 24.09.2010
• Subjects: CHEMISTRY; COMPOSITIONS BASED THEREON; HUMAN NECESSITIES; HYGIENE; MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONSONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC MACROMOLECULAR COMPOUNDS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; THEIR PREPARATION OR CHEMICAL WORKING-UP

PURPOSE: A multi-functional contrast agent is provided to secure the biodegradation property by applying multiple functional groups to a poly-succinimidyl-type polymer, and to minimize the organism rejection. CONSTITUTION: A multi-functional contrast agent includes the following: a poly-succinimidyl-type polymer including a poly-succinimide synthesized from maleic anhydride as a backbone; a hydrophilic group induced from polyethylene glycol, polyvinylpyrrolidone, dextran, polyethylene oxide, polylysine, or polyvinylalcohol; a hydrophobic group induced from an amine group with 3~80 carbons, or phospholipid; and an alkanol amine group collecting a contrast agent selected from the group consisting of gadolinium, manganese, a ferric oxide, aluminum, silicon, barium, yttrium, and a rare earth material.