PYRIDIN-2-YL-AMINO-1,2,4-THIADIAZOLE DERIVATIVES AS GLUCOKINASE ACTIVATORS FOR THE TREATMENT OF DIABETES MELLITUS

Provided are compounds of Formula (I): wherein R, R, R, L and Dare as defined in the specification, which are useful in the treatment and/or prevention of diseases or disorders mediated by deficient levels of glucokinase activity or which can be treated by activating glucokinase including, but not l...

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Main Authors HINKLIN RONALD JAY, TURNER TIMOTHY M, FISCHER JOHN P, FELL JAY BRADFORD, WALLACE ELI M, CONDROSKI KEVIN RONALD, CHICARELLI MARK JOSEPH, GUNAWARDANA INDRANI W, AICHER THOMAS DANIEL, SINGH AJAY, BOYD STEVEN ARMEN
Format Patent
LanguageEnglish
Korean
Published 12.07.2010
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Provided are compounds of Formula (I): wherein R, R, R, L and Dare as defined in the specification, which are useful in the treatment and/or prevention of diseases or disorders mediated by deficient levels of glucokinase activity or which can be treated by activating glucokinase including, but not limited to, diabetes mellitus, impaired glucose tolerance, IFG (impaired fasting glucose) and IFG (impaired fasting glycemia), as well as other diseases and disorders such as those discussed herein.
Bibliography:Application Number: KR20107008594