1-OXO-ISOINDOLINE-4-CARBOXAMIDE AND 1-OXO-1,2,3,4-TETRAHYDROISOQUINOLINE-5-CARBOXAMIDE DERIVATIVES, PREPARATION AND THERAPEUTIC USE THEREOF

• Main Authors: BAUDOIN BERNARD, GENEVOIS BORELLA ARIELLE, MALLERON JEAN LUC, MATHIEU MAGALI, EVERS MICHEL, KARLSSON ANDREAS
• Format: Patent
• Language: English; Korean
• Published: 18.05.2010
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention relates to 1-oxo-isoindoline-4-carboxamide and 1-oxo-1,2,3,4-tetrahydroisoquinoline-5-carboxamide derivatives of general formula (I) where: R1 = H, C-Calkyl, C-Ccycloalkyl, (CH)-(C-C)alkenyl, (CH)n-(C-C)alkynyl, (C-C)alkyl-Z-(C-C)alkyl, where Z = a heteroatom chosen from O, N and S(O), or R1 = COOR, S(O)R, aryl or aralkyl, R2 = one or more of H, halogen, C-Calkyl, C-Ccycloalkyl, C-Calkenyl, C-Calkynyl, C-Calkyl-Z-(C-C)alkyl, where Z = a heteroatom chosen from O, N and S(O), or R2 = halo(C-C)alkyl, C-Calkoxy, halo(C-C)alkoxy, hydroxy, nitro, cyano, amino, NR7R8, COOR, CONR7R8, O-CO(C-C)alkyl, S(O)-NR7R8, aryl; R3 = trifluoromethyl;R4 and R5 independently = H, or R4 and R5 together with the carbon to which they are attached form a saturated ring with 3 to 6 C and optionally containing O to 1 heteroatoms chosen from O, N or S; R6 = H,halogen, C-Calkyl, C-Ccycloalkyl, C-Ccycloalkyl-(C-C)alkyl, halo(C-C)alkyl, nitro, amino, NR7R8, COOR, NR7(SO2)R8, CONR7R8, aryl or heterocycle; X = C-Calkylene; m = a whole number from O to 2 and n = a whole number from1 to 6.