PROCESS FOR PRODUCTION OF CIS-3-SUBSTITUTED-3-AZABICYCLO[3.2.1]OCTAN-8-OL DERIVATIVE

Disclosed is a process for producing a cis-3-substituted-3-azabicyclo[3.2.1]octan-8-ol derivative, which is characterized by isomerizing a trans-3-substituted-3-azabicyclo[3.2.1]octan-8-ol derivative or a mixture of a trans-3-substituted-3-azabicyclo[3.2.1]octan-8-ol derivative and a cis-3-substitut...

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Bibliographic Details
Main Authors HAKUTA HIROSHI, OOOKA HIROHITO, IMAGAWA TSUTOMU, FUKUHARA SHINYA
Format Patent
LanguageEnglish
Korean
Published 30.03.2010
Subjects
APPARATUS THEREFOR
CHEMISTRY
GENERAL METHODS OF ORGANIC CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:Disclosed is a process for producing a cis-3-substituted-3-azabicyclo[3.2.1]octan-8-ol derivative, which is characterized by isomerizing a trans-3-substituted-3-azabicyclo[3.2.1]octan-8-ol derivative or a mixture of a trans-3-substituted-3-azabicyclo[3.2.1]octan-8-ol derivative and a cis-3-substituted-3-azabicyclo[3.2.1]octan-8-ol derivative in the presence of an aluminum compound represented by the formula: Al(OR)[wherein Rrepresents a hydrocarbon group in which the carbon having an oxygen atom bound thereto is a secondary carbon]. In the process, a ketone compound may be further added, in addition to the aluminum compound.
Bibliography:Application Number: KR20107003707