2-SUSTITUTEDAMINOALKYLENYLOXY-3-SUBSTITUTEDPHENYLETHYNYL-6-AMINOQUINOXALINE DERIVATIVES

PURPOSE: A novel 2-substitution amino alkenyloxy-3-substitution phenylethynyl-6-aminoquinoxaline derivative is provided to suppress WNT gene expression and ensure excellent anti-cancer activity. CONSTITUTION: A 2-substitution amino alkenyloxy-3-substitution phenylethynyl-6-aminoquinoxaline derivativ...

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Bibliographic Details
Main Authors LEE, TAE IM, GONG, YOUNG DAE, DONG, MI SOOK, LEE, SANG BUM, HWANG, SOON HEE
Format Patent
LanguageEnglish
Published 12.02.2010
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:PURPOSE: A novel 2-substitution amino alkenyloxy-3-substitution phenylethynyl-6-aminoquinoxaline derivative is provided to suppress WNT gene expression and ensure excellent anti-cancer activity. CONSTITUTION: A 2-substitution amino alkenyloxy-3-substitution phenylethynyl-6-aminoquinoxaline derivative is denoted by chemical formula 1. A method for preparing the 2-substitution amino alkenyloxy-3-substitution phenylethynyl-6-aminoquinoxaline derivative comprises: a step of performing Sonogashira reaction of ethynyl group donor reagent of chemical formula 3 with 2,3-dichloro-6-aminoquinoxaline of chemical formula 2 to obtain ethynyl compound of chemical formula 4; a step of reacting the ethynyl compound with alcohol compound of chemical formula 5 under the base presence to obtain the compound of chemical formula 1.
Bibliography:Application Number: KR20080076221