THE METHOD FOR PRODUCING QUERCETIN-7-O-RHAMNOSIDE

• Main Authors: LIM, YOONG HO, LEE, CHAE WOON, CHONG, YOU HOON
• Format: Patent
• Language: English
• Published: 22.01.2010
• Subjects: CHEMISTRY; CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION ORPROCESSING OF GOODS; DERIVATIVES THEREOF; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; METALLURGY; NUCLEIC ACIDS; NUCLEOSIDES; NUCLEOTIDES; ORGANIC CHEMISTRY; STEROIDS; SUGARS; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS; TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINSTCLIMATE CHANGE

PURPOSE: A producing method for quercetin-7-O-rhamnoside rhamnoside is provided to effectively use the quercetin-7-O-rhamnoside rhamnoside in various parts in which an antiviral material is required. CONSTITUTION: Peracetylated quercetin-7-O-rhamnoside is processed by reacting 2,3,4-tri-O-acetyl rhamnose-1-O-acetic acid imidate with 3,3',4',5-tetra-O-acetyl quercetin. A hydroxyl protection group is removed from the peracetylated quercetin-7-O-rhamnoside. The 3,3',4',5-tetra-O-acetyl quercetin selectively removes hydroxyl protecting group of a 7th position from 3,3',4',5,7-penta-O-acetyl quercetin, and is processed through a restoration by a hydroxyl group. The hydroxyl protecting group is acetyl group. The 2,3,4-tri-O-acetyl rhamnose-1-O-acetic acid imidate is processed by a react that the hydroxyl group of the 2,3,4-tri-O-acetyl rhamnose is changed to a leaving group. The 2,3,4-tri-O-acetyl rhamnose selectively removes in 1,2,3,4-tetra-O-acetyl rhamnose to a 1st position of the hydroxyl protection group, and is processed through a restoration by the hydroxyl group. 1,2,3,4-tetra-O-acetyl rhamnose is processed by a reaction that the hydroxyl protecting group is applied to L- rhamnose.