PROCESS FOR PREPARING 2-AMINO-5-CYANOBENZOIC ACID DERIVATIVES

Disclosed is a method for preparing a compound of Formula (1) comprising contacting a compound of Formula (2) with a metal cyanide reagent, a copper (I) salt reagent, an iodide salt reagent and at least one compound of Formula (3): wherein R1 is NHR3 or OR4; R2 is CH3 or Cl; R3 is H, C1-C4 alkyl, cy...

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Bibliographic Details
Main Authors BRUENING JOERG, SHAPIRO RAFAEL, ANNIS GARY DAVID, DUMAS DONALD JOSEPH, CURRIE MARTIN JAMES
Format Patent
LanguageEnglish
Korean
Published 11.09.2009
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:Disclosed is a method for preparing a compound of Formula (1) comprising contacting a compound of Formula (2) with a metal cyanide reagent, a copper (I) salt reagent, an iodide salt reagent and at least one compound of Formula (3): wherein R1 is NHR3 or OR4; R2 is CH3 or Cl; R3 is H, C1-C4 alkyl, cyclopropyl, cyclopropylcyclopropyl, cyclopropylmethyl or methylcyclopropyl; R4 is H or C1-C4 alkyl; Y is Br or Cl; X is NR13 or O; n is 0 or 1; and R5, R6, R7, R8, R9, R10, R11, R12 and R13 are as defined in the disclosure. Also disclosed is a method for preparing a compound of Formula (2) wherein Y is Br and R1 is NHR3 comprising introducing a gas containing bromine into a liquid containing a compound of Formula (4), and further disclosed is a method for preparing a compound of Formula (5) wherein R14, R15, R16 and Z are as defined in the disclosure using a compound of Formula (1) characterized by preparing the compound of Formula (1) by the method disclosed above.
Bibliography:Application Number: KR20097015132