MONO-PEGYLATED BASIC FIBROBLAST GROWTH FACTOR VARIANTS AND USES THEREOF

A mono-PEgylated bFGF(basic fibroblast growth factor) mutant is provided to has cell proliferation effect and increase time for remaining inside body. A mono-PEgylated bFGF mutant comprises additional Cys residue at N-terminal or C-terminal. The additional Cys residue is conjugated with PEG(polyethy...

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Main Authors CHUNG, YOUNG JI, BYUN, MIN SU, KIM, EUN MI, CHOI, JEONG JIN, KIM, YOUNG DEUG, CHOI, JUN YOUNG
Format Patent
LanguageEnglish
Published 03.08.2009
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPIRITS
VINEGAR
WINE
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Summary:A mono-PEgylated bFGF(basic fibroblast growth factor) mutant is provided to has cell proliferation effect and increase time for remaining inside body. A mono-PEgylated bFGF mutant comprises additional Cys residue at N-terminal or C-terminal. The additional Cys residue is conjugated with PEG(polyethylene glycol) single molecule. The additional Cys residue is conjugated with C-terminal of native bFGF. A composition for improving skin condition and treating wound comprises the mono-PEgylated bFGF mutant as an active ingredient. The composition is pharmaceutical composition or cosmetic composition.
Bibliography:Application Number: KR20080009001