A METHOD FOR PREPARING SOMATOSTATIN ANALOGUES PEPTIDES USING BY SOLID PHASE SYNTHESIS

A method for producing a somatostatin analogues using solid phase synthesis method is provided to manufacture a peptide of high purity and yield by fixing a side chain of cystein on the solid phase support. A method for producing somastatin of the structure formula (a) or octreotide of the structure...

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Bibliographic Details
Main Authors LEE, HAN WON, CHA, KYUNG HOI, LIM, DAE SUNG
Format Patent
LanguageEnglish
Korean
Published 07.07.2009
Subjects
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
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Summary:A method for producing a somatostatin analogues using solid phase synthesis method is provided to manufacture a peptide of high purity and yield by fixing a side chain of cystein on the solid phase support. A method for producing somastatin of the structure formula (a) or octreotide of the structure formula (b) comprises: a step of binding a sided chain of cystein or C-terminal on solid support resin; a step of synthesizing the peptide by binding amino acid derivative in the resin; and a step of performing peptide separation and cyclization through disulfide chain. The amino acid derivatives is protected by the protection group of Boc(tert-butoxycarbonyl), Fmoc(9-fluorenylmethoxycarbonyl), Cbz(benzyl-oxycarbonyl), tBu(tert-butyl), StBu(tert-butylthio), Trt(triphenyl-methyltrityl), Acm(acetamidomethyl) Tacm(trimethylacetamidomethyl) or Tmob(2,4,6-trimethoxybenzyl). The cyclization through disulfide chain is the TFA(trifluoroacetic acid).
Bibliography:Application Number: KR20080000060