RAS FUSION PROTEIN

A Ras fusion protein, which a part of N-Ras protein and a part of H-Ras protein are combined, is provided to identify interaction between Ras protein signal pathway and cancer generation and develop the molecule target cancer theraphy. A Ras fusion protein has a form which the first to nth amino aci...

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Bibliographic Details
Main Authors YONG, HAE YOUNG, MOON, A REE
Format Patent
LanguageEnglish
Korean
Published 02.07.2009
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
ORGANIC CHEMISTRY
PEPTIDES
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPIRITS
VINEGAR
WINE
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Summary:A Ras fusion protein, which a part of N-Ras protein and a part of H-Ras protein are combined, is provided to identify interaction between Ras protein signal pathway and cancer generation and develop the molecule target cancer theraphy. A Ras fusion protein has a form which the first to nth amino acid of a N-Ras (neuroblastoma-Ras) protein and n+1th to 189th amino acid of H-Ras(Harvey-Ras) protein are combined, and n is integer under 165. The fusion protein has the combination form of 1-120th amino acid of N-Ras protein and 121-189th amino acid of H-Ras protein. The fusion protein has the combination form of 1-141th amino acid of N-Ras protein and 142-189th amino acid of H-Ras protein. The fusion protein has the combination form of 1-165th amino acid of N-Ras protein and 166-189th amino acid of the H-Ras protein. The 12th amino acid of the fusion protein is substituted with Asp for Gly.
Bibliography:Application Number: KR20070140139