A NEW PEPTIDE DEFORMYLASE INHIBITOR COMPOUND AND MANUFACTURING PROCESS THEREOF

A novel compound, a method for preparing the compound, and an antibacterial composition containing the compound are provided to obtain a compound useful as a peptide deformylase inhibitor and showing an activity against the bacterial having tolerance to the already-known antibiotics. A novel peptide...

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Bibliographic Details
Main Authors KANG, JAE HOON, YU, SEUNG WOO, LEE, HEE YEOL, CHO, BONG HWAN, AN, KYUNG MI
Format Patent
LanguageEnglish
Published 11.12.2008
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:A novel compound, a method for preparing the compound, and an antibacterial composition containing the compound are provided to obtain a compound useful as a peptide deformylase inhibitor and showing an activity against the bacterial having tolerance to the already-known antibiotics. A novel peptide deformylase inhibitor compound is represented by the formula I, wherein A is -C(=O)NHOH or -N(CHO)OH; R1 is H, a C1-C3 alkyl group, a C4-C6 cycloalkyl group, a halogen atom, or a hydroxyl group; R2 is H, a linear or branched C1-C6 alkyl group, a linear or branched C2-C6 alkenyl group, a C4-C6 cycloalkyl group, a phenyl group, or a benzyl group; X is H or NR4R5; R4 and R5 are independently H, a linear or branched C1-C3 alkyl group, a t-butoxycarbonyl group, or a benzyloxycarbonyl group; and W is C or N.
Bibliography:Application Number: KR20070055482