A NEW N-FORMYL HYDROXYLAMINE COMPOUND AS INHIBITOR OF PEPTIDE DEFORMYLASE AND MANUFACTURING PROCESS THEREOF

• Main Authors: KANG, JAE HOON, YU, SEUNG WOO, LEE, HEE YEOL, CHO, BONG HWAN, AN, KYUNG MI
• Format: Patent
• Language: English
• Published: 12.06.2008
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; METALLURGY; ORGANIC CHEMISTRY

A new N-formyl hydroxylamine compound as an inhibitor of peptide deformylase is provided to improve safety of use, treat respiratory disease by inhibiting growth of Streptococcus pneumonia, and show anti-bacterial activity against antibiotic-resistance bacteria. A anti-bacterial N-formyl hydroxylamine compound represented by the formula(1) or pharmaceutically acceptable salts thereof is provided as an inhibitor of peptide deformylase, wherein R1 is hydrogen, C1-3 alkyl, C4-6 cycloalkyl, halogen or hydroxyl; R2 is hydrogen, linear or branched C1-6 alkyl, linear or branched C2-6 alkene, C4-6 cycloalkyl, C4-6 heterocycle having N or O, or benzyl; R3 is hydrogen, linear or branched C1-6 alkyl, linear or branched C2-6 alkene, C4-6 cycloalkyl, phenyl or benzyl; A is selected from compounds represented by the formula(IIa), formula(IIb) and formula(IIc); R4 is hydrogen, linear or branched C1-6 alkyl, C3-6 cycloalkyl, phenyl or halogen-substituted phenyl; R5 and R6 are each independently hydrogen or halogen; Q is O or N-R7 or CH-R7; R7 is hydrogen or C1-3 alkyl; and n is 0 or 1.