SYNTHESIS OF SILICA IMPREGNATED WITH NANOSIZED LIPOSOME EMULSION COMPRISING COENZYME Q10 AND COSMETIC COMPOSITIONS USING IT
A silica impregnating nanosized liposome emulsion including coenzyme Q10 is provided to stabilize the coenzyme Q10 by preparing a nano-sized liposome emulsion through application of a nano-technique and then impregnating the emulsion with a porous silica, thereby being applied to various cosmetic co...
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Main Authors | , , , |
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Format | Patent |
Language | English |
Published |
26.03.2008
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Subjects | |
Online Access | Get full text |
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Summary: | A silica impregnating nanosized liposome emulsion including coenzyme Q10 is provided to stabilize the coenzyme Q10 by preparing a nano-sized liposome emulsion through application of a nano-technique and then impregnating the emulsion with a porous silica, thereby being applied to various cosmetic compositions. A method for preparing a silica impregnating nanosized liposome emulsion including coenzyme Q10 comprises the steps of: (1) 20.0-80.0 parts by weight of a solvent having two hydroxy groups, 1.0-10.0 parts by weight of lecithin, 0.01-4.0 parts by weight of ceramide, 0.01-4.0 parts by weight of cholesterol, 0.005-2.0parts by weight of an oil soluble antioxidizer and 0.5-2.0 parts by weight of glyceryl behenate/eicosadioate and heating it at a temperature of 65-80 deg.C to prepare an oil phase portion; (b) mixing 0.5-25.0 parts by weight of coenzyme Q10, 1.0-40.0 parts by weight of emollient oil, 0.1-10.0 parts by weight of diethyl sebacate and heating it at a temperature of 45-60 deg.C to prepare an active material portion; (c) mixing 0.5-30.0 parts by weight of water and 0.005-1.0 parts by weight of a water soluble antioxidizer and heating it at a temperature 35-55 deg.C to prepare an aqueous phase portion; (d) after putting the active material portion in the oil phase portion with agitating it at the rotation speed of 1,000-2,000 rpm using a conventional agitator, putting the aqueous phase portion therein with agitating at the rotation speed of 1,000-2,000 rpm to form a first concentrated phase; (e) putting the first concentrated phase in a high pressure type emulsifier at a temperature of 45-65 deg.C and emulsifying the concentrated phase with the pressure of 600-1,500 bar one or two time(2) to form a liposome emulsion having a size of 100 nanometers; (f) cooling the liposome emulsion to a temperature of 30-40 deg.C to stabilize it; (g) after mixing 0.1-60 parts by weight of the liposome emulsion with 1-10 parts by weight of tetraethylorthosilicate with agitating at the rotation speed of 1,000-2,000 rpm for 10 minutes, putting an aqueous solution of sodium hydroxide therein and then leaving it for 3-5 hours to generate silica; and (h) isolating the silica from the reaction solution after completion of the silica generation, washing it with water, drying it and then treating it. |
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Bibliography: | Application Number: KR20060092242 |