OLIGOMER PROBE ARRAY HAVING PROBE CELL ACTIVE WITH INACTIVATED EDGE WALL AND FABRICATION METHOD THEREOF

• Main Authors: CHI, SUNG MIN, KIM, KYOUNG SEON, RYOO, MAN HYOUNG, KIM, WON SUN, HAH, JUNG HWAN, CHOI, SANG JUN
• Format: Patent
• Language: English
• Published: 19.02.2008
• Subjects: BEER; BIOCHEMISTRY; CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY; CHEMISTRY; COMBINATORIAL CHEMISTRY; COMPOSITIONS OR TEST PAPERS THEREFOR; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES; ENZYMOLOGY; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; LIBRARIES, e.g. CHEMICAL LIBRARIES, IN SILICOLIBRARIES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MEASURING; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS; METALLURGY; MICROBIOLOGY; MUTATION OR GENETIC ENGINEERING; NANOTECHNOLOGY; PERFORMING OPERATIONS; PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL; PHYSICS; PROCESSES OF PREPARING SUCH COMPOSITIONS; SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; SPIRITS; TESTING; THEIR RELEVANT APPARATUS; TRANSPORTING; VINEGAR; WINE

An oligomer probe array is provided to show increased signal to noise ratio(SNR) and decreased cross-talk, thereby increasing the accuracy of analysis. An oligomer probe array comprises: a substrate; a plurality of probe cell actives formed on the substrate, each of the probe cell actives coupled to a linker excluding the edge side wall thereof to inactivate the edge side wall; a probe cell separation region separating the plurality of probe cell active and not including a functional group coupled to the oligomer probe; and a plurality of oligomer probe coupled to the linker of the probe cell active. A method for preparing an oligomer probe array comprises the steps of: (a) providing a substrate; (b) forming a plurality of probe cell active separated by probe cell separation regions on the substrate; (c) forming partition walls having a higher thickness than that of a plurality of probe cell on the probe cell separation region; (d) after spin-coating a linker solution on the substrate, spin-drying the non-reacted linker solution and baking the remaining linker solution; and (e) removing the partition walls to allow the linker to be coupled to the region excluding the edge side wall of each of the probe cell active.