MUTANTS HAVING A HIGH PRODUCING ABILITY OF 1,2-PROPANEDIOL AND METHOD FOR PREPARING 1,2-PROPANEDIOL USING THE SAME

Mutants having high producing ability of 1,2-propanediol are provided to increase production yield of 1,2-propanediol and reduce separation and purification costs by reducing production of by-products based on the glycerolipid metabolism pathway. A mutant having high 1,2-propanediol-producing abilit...

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Main Authors SONG, HYO HAK, JANG, SEH HEE, JUNG, KWANG SEOP, CHOI, HYUNG SEOK, HASINA PARVIN HUQ, KIM, JAE HYUN, LEE, SANG YUP
Format Patent
LanguageEnglish
Published 27.12.2007
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPIRITS
VINEGAR
WINE
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Summary:Mutants having high producing ability of 1,2-propanediol are provided to increase production yield of 1,2-propanediol and reduce separation and purification costs by reducing production of by-products based on the glycerolipid metabolism pathway. A mutant having high 1,2-propanediol-producing ability is produced by introducing or amplifying a gene encoding an enzyme for converting glycerol into 2-hydroxypropanal and a gene encoding an enzyme for converting 2-hydroxypropanal into 1,2-propanediol in a microorganism having glycerol-producing ability or being able to use glycerol as a carbon source, which is selected from bacteria, yeasts and fungi, wherein a gene encoding an enzyme for converting 2-hydroxypropanal into glycerol and a gene encoding an enzyme for converting 1,2-propanediol into 2-hydroxypropanal are deleted in the mutant. The 1,2-propanediol is produced by culturing the mutant and isolating 1,2-propanediol from the cultured medium.
Bibliography:Application Number: KR20060056117