MONOCLONAL ANTIBODY AGAINST PRES1, SURFACE ANTIGEN OF HEPATITIS B VIRUS

• Main Authors: KIM, SANG JICK, KIM, JIN HONG, LIM, JI HYE, JANG, MYUNG HEE, RYU, CHUN JEIH, HONG, HYO JEONG, AHN, HYUN JOO
• Format: Patent
• Language: English
• Published: 09.10.2007
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPIRITS; VINEGAR; WINE

A humanized antibody against a surface antigen pre-S1 of Hepatitis B virus(HBV) is provided to secure the antigen binding capacity similar to that of a mouse monoclonal antibody and have significantly decreased immunity inducing capacity in human due to having more humanized amino acid residue, thereby being usefully used for preventing and treating HBV infection. A humanized antibody against a surface antigen pre-S1 of HBV is characterized in that an amino acid sequence of a heavy chain region is described as SEQ ID : NO. 10 or an amino acid sequence of a light chain region is described as SEQ ID : NO. 20. An expression vector comprises a gene coding an amino acid sequence described as SEQ ID : NO. 19, a gene coding an amino acid sequence described as SEQ ID : NO. 20, and a chimera antibody coding an invariable region of a human IgG antibody. A composition for preventing and treating Hepatitis B comprises a chimera antibody expressed by the expression vector. A kit for detecting HBV comprises the antibody.