MONOCLONAL ANTIBODY AGAINST PRES1, SURFACE ANTIGEN OF HEPATITIS B VIRUS

A humanized antibody against a surface antigen pre-S1 of Hepatitis B virus(HBV) is provided to secure the antigen binding capacity similar to that of a mouse monoclonal antibody and have significantly decreased immunity inducing capacity in human due to having more humanized amino acid residue, ther...

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Main Authors KIM, SANG JICK, KIM, JIN HONG, LIM, JI HYE, JANG, MYUNG HEE, RYU, CHUN JEIH, HONG, HYO JEONG, AHN, HYUN JOO
Format Patent
LanguageEnglish
Published 09.10.2007
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
ORGANIC CHEMISTRY
PEPTIDES
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPIRITS
VINEGAR
WINE
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Summary:A humanized antibody against a surface antigen pre-S1 of Hepatitis B virus(HBV) is provided to secure the antigen binding capacity similar to that of a mouse monoclonal antibody and have significantly decreased immunity inducing capacity in human due to having more humanized amino acid residue, thereby being usefully used for preventing and treating HBV infection. A humanized antibody against a surface antigen pre-S1 of HBV is characterized in that an amino acid sequence of a heavy chain region is described as SEQ ID : NO. 10 or an amino acid sequence of a light chain region is described as SEQ ID : NO. 20. An expression vector comprises a gene coding an amino acid sequence described as SEQ ID : NO. 19, a gene coding an amino acid sequence described as SEQ ID : NO. 20, and a chimera antibody coding an invariable region of a human IgG antibody. A composition for preventing and treating Hepatitis B comprises a chimera antibody expressed by the expression vector. A kit for detecting HBV comprises the antibody.
Bibliography:Application Number: KR20060030309