DE-DIFFERENTIATION OF ASTROCYTES INTO NEURAL STEM CELL USING NANOG

A composition comprising a Nanog protein is provided to induce de-differentiation of astrocytes into neural stem cell, thereby being able to treat various diseases by using the de-differentiated neural stem cell. The composition comprises a Nanog protein or a nucleic acid including a nucleotide sequ...

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Main Authors KWAK, SUNG SIK, YOU, SEUNG KWON, KIM, KI DONG, MOON, JAI HEE, YOON, BYUNG SUN, MAENG, ISAAC, JUN, EUN KYOUNG, KIM, BO NA, PARK, GYU MAN, YOO, SEUNG JUN
Format Patent
LanguageEnglish
Published 30.08.2007
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPIRITS
VINEGAR
WINE
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Summary:A composition comprising a Nanog protein is provided to induce de-differentiation of astrocytes into neural stem cell, thereby being able to treat various diseases by using the de-differentiated neural stem cell. The composition comprises a Nanog protein or a nucleic acid including a nucleotide sequence coding a Nanog protein. The method for inducing de-differentiation of astrocytes into neural stem cell comprises the steps of: (a) culturing astrocytes in a culture medium; (b) treating the astrocytes with the Nanog protein or the nucleic acid including the nucleotide sequence coding the Nanog protein; and (c) inducing the de-differentiation of the astrocytes into neural stem cell.
Bibliography:Application Number: KR20060019012