MIXED SOLVATE OF OLANZAPINE, METHOD FOR PREPARING IT AND METHOD FOR PREPARING FORM I OF OLANZAPINE THEREFROM

Said mixed solvate is a solvate of olanzapine/water/tetrahydrofuran in the proportion 1:1:1/2 (I). The method for preparing said solvate comprises treating a crude anhydrous olanzapine with a mixture of tetrahydrofuran/water. The method for preparing Form I of olanzapine includes desolvating the mix...

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Bibliographic Details
Main Authors DALMASES BARJOAN PERE, BESSA BELLMUNT JORDI
Format Patent
LanguageEnglish
Published 19.06.2007
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:Said mixed solvate is a solvate of olanzapine/water/tetrahydrofuran in the proportion 1:1:1/2 (I). The method for preparing said solvate comprises treating a crude anhydrous olanzapine with a mixture of tetrahydrofuran/water. The method for preparing Form I of olanzapine includes desolvating the mixed solvate of formula I, by means of drying, in vacuo and under temperature-controlled conditions.
Bibliography:Application Number: KR20077002091