NOVEL GLP-1 ANALOGUES LINKED TO ALBUMIN-LIKE AGENTS

The present invention relates to a compound having the structure of the formula (I) : GLP-1 agonist-L-RR-protraction protein (I) wherein GLP-1 agonist is a polypeptide which is an agonist of the human GLP-1 receptor, L is a linker connecting an amino acid side chain of said GLP-1 agonist with RR, RR...

Full description

Saved in:
Bibliographic Details
Main Authors MADSEN KJELD, SVENDSEN ANNE, LAU JESPER, HANSEN THOMAS KRUSE, ZUNDEL MAGALI, SCHI?? DT CHRISTINE BRUUN
Format Patent
LanguageEnglish
Published 23.10.2006
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
Online AccessGet full text

Cover

More Information
Summary:The present invention relates to a compound having the structure of the formula (I) : GLP-1 agonist-L-RR-protraction protein (I) wherein GLP-1 agonist is a polypeptide which is an agonist of the human GLP-1 receptor, L is a linker connecting an amino acid side chain of said GLP-1 agonist with RR, RR is the remains of a reactive residue that has formed a covalent bond with an amino acid residue of the protraction protein, and protraction protein is a protein having a molar weight of at least 5 kDa, having a plasma halflife of at least 24 hours in human plasma, and said protraction protein has been synthesised by a non-mammalian organism or synthetically.
Bibliography:Application Number: KR20067011910