T-TYPE CALCIUM CHANNEL INHIBITOR

A T-type calcium channel inhibitor which is any of a compound represented by the formula (1): [Chemical formula 1] (1) [wherein Ar1 means phenyl, pyridyl, furyl, or 2,1,3- benzoxadiazol-4-yl; the nitrogenous heterocycle moiety is a 1,4- dihydropyridine ring or pyridine ring; Z means the formula (2):...

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Bibliographic Details
Main Authors MATSUMOTO HIROO, MASUDA YUKINORI, FURUKAWA TAIJI, YAMASHITA TORU, YAMADA OSAMU
Format Patent
LanguageEnglish
Published 11.09.2006
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:A T-type calcium channel inhibitor which is any of a compound represented by the formula (1): [Chemical formula 1] (1) [wherein Ar1 means phenyl, pyridyl, furyl, or 2,1,3- benzoxadiazol-4-yl; the nitrogenous heterocycle moiety is a 1,4- dihydropyridine ring or pyridine ring; Z means the formula (2): [Chemical formula 2] (2) or CO2R2; Ra and Rb each independently means C1-6 alkyl, ANR8R9, CH2OANR8R9, etc.; when the nitrogenous heterocycle means a 1,4-dihydropyridine ring, then R1 means C 1-6 alkyl, ANR8R9, AN(CH2CH2) 2NR8, AN(CH2CH2)2O, AOR8, or benzyl; and R3 means hydrogen, C1-20 alkyl, ANR 8R9, or a group represented by any of the following formulae], [Chemical formula 3] a pharmaceutically acceptable salt of the compound, and a solvate of either.
Bibliography:Application Number: KR20067012135