SUSTAINED-RELEASE PELLET FOR TAMSULOSIN HYDROCHLORIDE AND THEIR METHOD OF PREPARATION

PROBLEM TO BE SOLVED: To obtain a sustained release pellet composition for oral administration of tamsulosin hydrochloride having a uniform elution rate, and to provide a method for producing the same. SOLUTION: The sustained release pellet composition for oral administration of tamsulosin hydrochlo...

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Main Authors PARK, HO SEOK, CHOI, KYU SANG, HWANG, WOO SIN, LEE, IL KYU, BANG, KYU HO, HWANG, DONG HYUCK, YUN, DUCK IL
Format Patent
LanguageEnglish
Published 19.07.2005
Edition7
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:PROBLEM TO BE SOLVED: To obtain a sustained release pellet composition for oral administration of tamsulosin hydrochloride having a uniform elution rate, and to provide a method for producing the same. SOLUTION: The sustained release pellet composition for oral administration of tamsulosin hydrochloride contains the followings (a), (b) and (c). (a) 300-1,000 pts. wt. core; (b) a primary release-adjusting layer containing 1 pt. wt. tamsulosin hydrochloride, 200-600 pts. wt. primary release-adjusting agent selected from the group consisting of a methacrylic acid-ethyl acrylate copolymer, an ethyl cellulose and a polyvinyl acetate and 0.5-3 pts. wt. releasing assistant of at least ≥1 kind selected from the group consisting of an alginic acid salt, microcrystalline cellulose and sodium salt of carboxymethylcellulose; and (c) a secondary release-adjusting layer containing 1-10 pts. wt. secondary release-adjusting agent selected from the group consisting of ethylcellulose, Eudragit L100 and Eudragit S100. COPYRIGHT: (C)2005,JPO&NCIPI
Bibliography:Application Number: KR20040002656