ANALYTICAL METHOD OF PROTEIN STRUCTURE STABILITY BY THERMODYNAMIC ENERGY FUNCTIONS CONTAINING HIGH-DIMENSIONAL STRUCTURE OF PROTEINS

• Main Authors: HUH, MU YEONG, KIM, HAE JIN, JUNG, GWANG HUN, JANG, IK SU, KIM, SEOK MAN, CHUN, MU GYEONG, MUN, EUN JEONG
• Format: Patent
• Language: English; Korean
• Published: 07.07.2004
• Edition: 7
• Subjects: INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; PHYSICS; TESTING

PURPOSE: An analytical method of protein structure stability by thermodynamic energy functions containing high-dimensional structure of proteins is provided, thereby easily determining whether the protein structure to be analyzed is natural structure. CONSTITUTION: The analytical method of protein structure stability by thermodynamic energy functions containing high-dimensional structure of proteins comprises judging whether the new protein/protein group satisfies the mathematical equation 12 using the score parameters, wherein the score parameters are calculated by the mathematical equation 12 using the groups, wherein the groups comprise a plurality of training protein group showing the natural structure extracted from the protein data of which amino acid sequence and tertiary structure via X-ray determination are known; a training decoy structure protein group which is formed by corresponding the amino acid sequence of protein A having length of NA to from a first amino acid to NA amino acid of protein B having the same or longer length of NB than NA, and repeating the correspondence with increasing one amino acid position of protein B; score parameters calculated by the mathematical equation 12 using score function showing energy level when a sequence s has a structure of letter "L" and containing all kinds of amino acids and local environment; new protein/protein group which does not belong to the training protein group; and new decoy structure protein group which is formed by the same method of the training protein group using the training protein group.