Novel cephalosporin compounds and process for preparing same

• Main Authors: KOO, GI DONG, JANG, YONG JIN, LEE, CHANG SEOK, KIM, GEUN TAE, CHO, YANG RAE, JU, HYEONG RYEOL
• Format: Patent
• Language: English; Korean
• Published: 29.09.2003
• Edition: 7
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; METALLURGY; ORGANIC CHEMISTRY

PURPOSE: Provided are cephalosporin compounds and a preparation method thereof, which compounds have antimicrobial activity to the wide range of gram positive bacteria. CONSTITUTION: Cephalosporin compounds represented by formula (1), pharmaceutically acceptable nontoxic salts thereof, physiologically hydrolyzable esters, hydrides, solvates and isomers thereof are provided, wherein A is hydrogen or amino protecting group; R1 is hydrogen, one to three oxygen or halogen C1-6 alkyl, C3-4 alkenyl, one nitrogen containing C3-4 alkynyl, C3-6 cycloalkyl, C3-6 cycloalkyl-methyl or one to two nitrogen or oxygen containing C5-6 heteroarylmethyl; R2 is hydrogen or carboxyl protecting group; V is N or C; W is C, N or N+-U, in which W is C when V is N, and W is N or N+-U when V is C; U is C1-5 alkyl or amino; Y is hydrogen, hydroxyl, C1-6 alkyl, C1-6 alkyl substituted or unsubstituted amino, C1-6 hydroxyalkyl or C1-6 alkylthio; Z is a compound of I and J; I is S, SO or SO2; n is 1, 2, 3 or 4; J is C1-6 alkyl substituted or unsubstituted amino, hydroxy or substituted C1-6 alkoxy; Q is CH, CX' or N; and X' is halogen. 본 발명은 하기 화학식 (1)의 신규 세팔로스포린 화합물, 약제학적으로 허용되는 그의 무독성 염, 생리학적으로 가수분해 가능한 그의 에스테르, 수화물 및 용매화물 및 이들의 이성체, 이들을 함유하는 약제학적 조성물 및 그의 제조방법에 관한 것이다. 상기 식에서, A, Q, R, R, V, W, Y 및 Z는 각각 명세서에 언급된 바와 같다.