2 124- Diaryl 124-triazole derivatives as a highly selective cyclooxygenase-2 inhibitor

• Main Authors: KIM, JE HAK, KIM, JONG HUN, KIM, JONG HO, WANG, SO YEONG, LIM, JI UNG, RYU, CHUN SEON, CHO, IL HWAN, KIM, DAL HYEON, YOO, HYEONG CHEOL, NOH, JI YEONG, PARK, SANG UK
• Format: Patent
• Language: English; Korean
• Published: 04.07.2003
• Edition: 7
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

PURPOSE: Diaryl 1,2,4-triazol derivatives having high selective cyclooxygenase-2 inhibiting activity are provided, which improve the adverse effect of conventional nonsteroid anti-inflammatory drugs and are useful for treatment of inflammatory diseases. CONSTITUTION: Diaryl 1,2,4-triazol derivatives represented by the formula 1 as a cyclooxygenase-2 inhibitor and pharmaceutically acceptable salts thereof are provided, wherein R1, R2, R3, R4 and R5 are independently hydrogen or halogen, or halogen substituted or unsubstituted C1-C3 alkyl, NO2, NH2, OH, OMe, CO2H or CN; A is CH3 or NH2; and W is CH or N. 본 발명은 사이클로옥시게나제-2 에 대한 선택적인 저해활성을 갖는 신규한 하기 화학식 1 의 디아릴 1,2,4-트리아졸 유도체에 관한 것이다: [화학식 1] 상기식에서, R, R, R, R, R, W 및 A는 각각 명세서에 정의된 바와 같다.