Polysaccaride from the safflower having macrophage activity the process for preparation thereof and a use thereof

PURPOSE: An anticancer agent composition containing a water extract of Carthamus Tinctorius L. as an active ingredient is provided which can be used a medicament for immune disorders or cancer, or a functional food product. CONSTITUTION: Polysaccharides for activating macrophages are prepared by the...

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Bibliographic Details
Main Authors CHO, HONG YEON, JUN, U JIN, SHIN, DONG HUN, HONG, BEOM SIK, YANG, HAN CHEOL
Format Patent
LanguageEnglish
Korean
Published 08.04.2003
Edition7
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:PURPOSE: An anticancer agent composition containing a water extract of Carthamus Tinctorius L. as an active ingredient is provided which can be used a medicament for immune disorders or cancer, or a functional food product. CONSTITUTION: Polysaccharides for activating macrophages are prepared by the steps of: removing a methanol soluble fraction from an water extract of Carthamus Tinctorius L. and then precipitating it in ethanol; ultrafiltering the precipitates and recovering a solution having a molecular weight of 300,000Da or more; loading the solution into anion exchange resin, followed by fractionation with 0.1 mol NaCl solution; and subjecting an active fraction to gel filtration chromatography having a separation capacity of 10,000 to 1,000,000. 본 발명은 홍화로부터 분리한 대식세포 활성을 가지는 다당류, 이의 제조방법 및 이의 용도에 관한 것으로, 홍화의 냉수추출물을 에탄올 침전시킨 후 한외여과하여 분자량 30만 Da 이상의 고분자 물질을 수득하고, 상기 물질을 음이온 교환수지 크로마토그래피, 겔 여과 크로마토그래피를 하여 제조한 고분자 다당류는 대식세포 활성화능이 높아 면역증강제로서 뛰어난 효과가 있는 한편, 홍화의 한외여과한 수추출물은 항암활성을 가지고 있어, 암환자나 면역저하 환자용의 기능성 식품 및 약학적 조성물로 사용할 수 있다.
Bibliography:Application Number: KR20010059879