LOWER ALCOHOL INSOLUBLE EXTRACT AND A POLYSACCHARIDE THEREIN ISOLATED FROM HOVENIA DULCIS VAR. KOREANA NAKAI HAVING ANTIHEPATOTOXIC AND ANTI-HANGOVER ACTIVITY AND COMPOSITION CONTAINING SAME

• Main Authors: KIM, SE HYEON, JUNG, NAM CHEOL, NA, CHEON SU
• Format: Patent
• Language: English; Korean
• Published: 07.08.2002
• Edition: 7
• Subjects: CHEMISTRY; COMPOSITIONS BASED THEREON; COMPOUNDS OF UNKNOWN CONSTITUTION; DERIVATIVES THEREOF; FOODS OR FOODSTUFFS; FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BYSUBCLASSES A23B - A23J; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; ORGANIC MACROMOLECULAR COMPOUNDS; POLYSACCHARIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; THEIR PREPARATION OR CHEMICAL WORKING-UP; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OFNUTRITIVE QUALITIES, PHYSICAL TREATMENT; THEIR TREATMENT, NOT COVERED BY OTHER CLASSES

PURPOSE: An extract of Hovenia dulcis var. koreana or an active component separated therefrom is provided. It is useful as a preventive and therapeutic agent for various liver diseases and hangover because it exhibits excellent antihepatotoxic effects. CONSTITUTION: Hovenia dulcis var. koreana is extracted with hot water under pressure and added with low alcohol to produce a low alcohol-insoluble extract, which is subjected to ion exchange resin column chromatography in 0.2M sodium chloride solution to produce polysaccharides. These polysaccharides are also mixed with additives to produce health food for prevention of liver disease such as hepatitis or hepatocirrhosis, or hangover. 본 발명은 간보호 활성을 갖는 헛개나무(var.)의 과경 저급 알콜 불용성 추출분획 및 이로부터 정제 분리된 다당체 물질에 관한 것으로서, 이 저급 알콜 불용성 추출분획 및 다당체 물질은 사염화탄소, 지질 리포폴리사카라이드(LPS) 및 브로모벤젠에 의한 간독성을 효과적으로 치료함으로써, 간염, 간경화와 같은 간질환과 숙취의 치료 및 예방에 유용한 약학 조성물 및 간질환을 예방할 수 있는 건강식품으로서 사용될 수 있다.