BENZIMIDAZOL DERIVATIVE AND PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF

PURPOSE: A benzimidazol derivative and its pharmaceutically acceptable salts are provided, thereby inhibiting phosphodiesterase IV or tumor necrosis factor(TNF), and treating diseases associated with phosphodiesterase IV or tumor necrosis factor(TNF). CONSTITUTION: The benzimidazol derivative repres...

Full description

Saved in:
Bibliographic Details
Main Authors LEE, JAE MOK, KIM, JONG HUN, YOON, YEO HONG, LIM, JI UNG, LEE, JEONG GEUN, JANG, MYEONG SIK, SEO, BYEONG CHEOL, SONG, SEOK BEOM
Format Patent
LanguageEnglish
Korean
Published 03.06.2002
Edition7
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
Online AccessGet full text

Cover

More Information
Summary:PURPOSE: A benzimidazol derivative and its pharmaceutically acceptable salts are provided, thereby inhibiting phosphodiesterase IV or tumor necrosis factor(TNF), and treating diseases associated with phosphodiesterase IV or tumor necrosis factor(TNF). CONSTITUTION: The benzimidazol derivative represented by formula(1) and its pharmaceutically acceptable salts are provided. In the formula(1), R1 is methyl, ethyl, difluoromethyl or trifluoromethyl; R2 is (C1-C7)alkyl or (C3-C7)cycloalkyl; R3 is -CH=NR4 or -CH(CN)R5 wherein R4 is N containing (C2-C5)heteroaryl, N containing (C2-C5)heterocycloalkyl, N(C=X)NR6 or N(CH2)nCOR7 in which n is 0 to 5; R6 is hydrogen, (C1-C6)alkyl, (C3-C6)aryl, -(CH2)nCOR7, -(CH2)nCONH2 or -(CH2)nR8 in which n is 0 to 5; R7 is -OH or -OR1; R8 is (C3-C6)aryl or (C3-C6)cycloalkyl; and X is carbon, nitrogen, oxygen or sulfur.
Bibliography:Application Number: KR20000071159