Chemical substance for protection of brain nerve cell and method for producing thereof

• Main Authors: YOO, IN JA, YOO, IK DONG, KWAK, BYEONG JU, YOON, BONG SIK
• Format: Patent
• Language: English; Korean
• Published: 04.03.2002
• Edition: 7
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPIRITS; VINEGAR; WINE

PURPOSE: Provided are a neuron protector which inhibits apoptosis induced by excitotoxicity such as NMDA, AMPA, kainate and the like, and its manufacturing method. CONSTITUTION: The neuron protector, complestatin, is manufactured by steps of: identifying and culturing Streptomycessp.60190 strain(KCTC 0843 BP) which produces a neuron protector; then extracting aromatic peptide complestatin, which is represented by the formula(I) and has apoptosis inhibiting and neuron protecting activities, therefrom. 본 발명은 신규 기능의 뇌신경세포 보호물질 및 그 제조방법에 관한 것으로, 뇌신경세포 보호 활성이 있는 방선균 균주로부터 뇌신경세포 보호물질을 생산하는sp. 60910를 동정, 배양하고 그로부터 뇌신경세포 보호 활성이 있는 방향족 펩타이드인 컴플레스타틴 (complestatin)을 추출한 후 상기 화합물의 물리화학적 및 생물학적 활성을 측정한 결과, 신규 기능의 뇌신경세포 사멸을 억제하는 신경세포 보호물질임이 확인되어 이 물질과 함께 그 제조방법을 제공하는 뛰어난 효과가 있다.