Composition of essential oil having an inhibitary activity on the formation of leucotriens

• Main Authors: AHN, GYEONG SEOP, OH, SE RYANG, LEE, IM SEON, JANG, HYEON UK, LEE, HYEONG GYU, KIM, JEONG HUI, JUNG, GEUN YEONG, PARK, SI HYEONG
• Format: Patent
• Language: English; Korean
• Published: 12.09.2001
• Edition: 7
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

PURPOSE: Provided is a novel use of essential oil obtained by vapor distillation of plants and showing the inhibitory action against the production of leukotriene as a mediator of inflammation. CONSTITUTION: An inhibitor of leukotriene production comprises at least a compound selected from the group consisting of (-)-menthol, (+)-limonene, alpha-terpinene, gamma-terpinene, terpineol, beta-myrcene, (±)-linaloo, geraniol, citral, beta-cyclocitral, eugenol, safrole, (+)-alpha-pinene, (-)-alpha-pinene, and (+)-cis-verbenol, as an effective components. Preferably, the inhibitor comprises eugenol or safrole as an active ingredient. The inhibitor can be used for a variety of inflammatory diseases including asthma, whooping cough, psoriasis, arthritis, inflammatory intestine diseases, cystic fibrosis, chronic bronchitis, rheumatoid arthritis, septic shock, myocardial ischemia, cardiac anaphylaxis, cerebral vasospasm, ischemia and allergic rhinitis. 본 발명은 정유 (精油; essential oil)를 유효성분으로 함유하는 류코트리엔 생성 저해제용 약학적 조성물에 관한 것으로, 보다 상세하게는 주성분으로 (-)-멘톨 (menthol; 화학식 1), (+)-리모넨 (limonene; 화학식 2), α-테르피넨 (terpinene; 화학식 3), γ-테르피넨 (terpinene; 화학식 4), 테르피네올 (terpineol; 화학식 5), β-미르센 (myrcene; 화학식 6), (±)-리나룰 (linalool; 화학식 7), 게라니올 (geraniol; 화학식 8), 사이트랄 (citral; 화학식 9), β-사이클로사이트랄 (cyclocitral; 화학식 10), 유게놀 (eugenol; 화학식 11), 사프롤 (safrole; 화학식 12), (+)-α-피넨 (pinene; 화학식 13), (-)-α-피넨 (pinene; 화학식 14) 및 (+)--베르베놀 (verbenol; 화학식 15) 중에서 선택되는 하나 이상의 화합물을 포함하는 조성물은 류코트리엔 생성 저해제로서 류코트리엔과 관련된 질환의 예방, 치료 및 치료보조제로 유용하게 사용될 수 있다.