NEW PYRIDINE COMPOUNDS A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

• Main Authors: DEKEYNE ANNE, PEGLION JEAN-LOUIS, DESSINGES AIMEE, MILLAN MARK, POITEVIN CHRISTOPHE
• Format: Patent
• Language: English; Korean
• Published: 15.06.2001
• Edition: 7
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

PURPOSE: Pyridine derivatives (I), their isomers and pharmaceutically acceptable acid or base addition salts are provided. Also, their preparation method is provided. CONSTITUTION: Pyridine derivatives compounds represented by the formula(I), where, W is naphthyl, optionally substituted by one or more halogens, C1-C6 alkyl or alkoxy, OH, CN, NO2, C1-C6 trihaloalkyl, methylene dioxy, ethylene dioxy, or a group of formula(Y); n is 1-6; Z is a bond, O, N (substituted by H, C1-C6 alkyl or hydroxyalkyl), or aryl C1-C6 alkyl; A is CH or N; and Q is CH or N, such that at least one of A and Q is N, and A is N when Z is a bond; M together with the C atoms to which it is attached is thieno, furo, pyrrolo or oxopyrrolo; and E with the two C atoms to which it is attached is an unsaturated, partially saturated or aromatic 5-7 membered ring system having at least one hetero atom (O, N, S), being attached to the alkylene chain either through the phenyl or through the ring, and being optionally substituted by one or more halogens, OH, CN, NO2, 1-6C alkyl or alkoxy, C1-C6 trihaloalkyl, or heterocyclo C1-C6 alkylene, or oxo. 본 발명은 하기 화학식(I)의 화합물, 이들의 이성질체 및 이들과 약제학적으로 허용되는 산 또는 염기와의 부가염에 관한 것이다 : 상기 식에서, W는 치환되거나 비치환된 나프틸기 또는 본원에 정의된 바와 같은 화학식(Y)의 기()를 나타내고, n은 1 내지 6의 정수를 나타내고, Z는 단일 결합, 산소 원자 또는 치환되거나 비치환된 질소 원자를 나타내고, A 및 Q는 각각 CH기 또는 질소 원자를 나타내고, M은, 이들의 결합되는 페닐 고리의 탄소 원자와 함께 티에닐, 푸릴, 피롤릴 또는 옥소피롤릴기를 나타낸다.